I have the anti-parietal cell version of pernicious anemia and I inject every second day, and more through times of stress (I work large events). Your comment that injecting more than once a month is excessive and simply a placebo is dangerous and misinformed. I used to function just fine on 8–12 week injections then something happened, and over an 18 month period I started to need much, much more of it. My cells no longer retain their B12 longer than around 48 hrs. I am no ditzy hypochondriac nervous nelly. I now know the signs in my body when it’s time for another shot (dread, anxiety, brainfog, unusual fatigue). I know that stress, strenuous exercise, alcohol and nitrous oxide all deplete my B12 so I avoid all.

Please read the article I wrote about my journey and learnings.

I am so much better now I’m self-injecting every second day, my fitness is returning, my mental health is restored, my peripheral neuropathy is easing (still get burning feet and crazy itchy legs from time to time though). So much so that I’m about to confidently embark on a Bachelor Of Health Sciences majoring in Nutrition at the age of 51.

I would argue that the personal experiences (mine included) and internally developed protocol (managed by B12 specialists and healthcare professionals affected by B12 deficiency) of the 18K-member-strong Pernicious Anemia/B12 Deficiency Support Group provide great weight to the fact that a great many people need B12 injections far more often than others as they are unable to retain their B12 at a cellular level. We need to get more studies into the field to prove this, because the treatment misinformation out there in the medical guidelines is destroying lives. The blanket dismissal by GP’s and other practitioners of requests from patients for more regular B12 injections is arrogant and unnecessary given it’s a water soluble vitamin that has no upper level tolerable limit. Listen to your patients.